pI: 10.7688 |
Length (AA): 133 |
MW (Da): 14657 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 merozoite. | Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | ME49 Oocyst. | Fritz HM |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Ortholog group members (OG5_126675)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G03770 | cytosolic sulfotransferase 13 |
Arabidopsis thaliana | AT1G18590 | sulfotransferase 17 |
Arabidopsis thaliana | AT1G28170 | sulfotransferase 7 |
Arabidopsis thaliana | AT4G26280 | sulfotransferase 3 |
Arabidopsis thaliana | AT1G13430 | sulfotransferase 4C |
Arabidopsis thaliana | AT2G03760 | sulphotransferase 12 |
Arabidopsis thaliana | AT1G74090 | desulfo-glucosinolate sulfotransferase 18 |
Arabidopsis thaliana | AT1G13420 | sulfotransferase 4B |
Arabidopsis thaliana | AT2G03750 | cytosolic sulfotransferase 11 |
Arabidopsis thaliana | AT5G07000 | sulfotransferase 2B |
Arabidopsis thaliana | AT3G45070 | sulfotransferase 5 |
Arabidopsis thaliana | AT5G07010 | sulfotransferase 2A |
Arabidopsis thaliana | AT3G45080 | cytosolic sulfotransferase 6 |
Arabidopsis thaliana | AT5G43690 | sulfotransferase 1 |
Arabidopsis thaliana | AT2G27570 | P-loop containing nucleoside triphosphate hydrolases superfamily protein |
Arabidopsis thaliana | AT2G14920 | sulfotransferase 4A |
Arabidopsis thaliana | AT1G74100 | desulfo-glucosinolate sulfotransferase 16 |
Brugia malayi | Bm1_51335 | Sulfotransferase domain containing protein |
Caenorhabditis elegans | CELE_Y113G7A.11 | Protein SSU-1 |
Dictyostelium discoideum | DDB_G0274373 | hypothetical protein |
Drosophila melanogaster | Dmel_CG16733 | Sulfotransferase 2 |
Drosophila melanogaster | Dmel_CG44167 | Sulfotransferase 3 |
Homo sapiens | ENSG00000198203 | sulfotransferase family, cytosolic, 1C, member 2 |
Homo sapiens | ENSG00000198075 | sulfotransferase family, cytosolic, 1C, member 4 |
Homo sapiens | 27284 | sulfotransferase family, cytosolic, 1B, member 1 |
Loa Loa (eye worm) | LOAG_07209 | sulfotransferase domain-containing protein |
Mus musculus | ENSMUSG00000029269 | sulfotransferase family 1B, member 1 |
Mus musculus | ENSMUSG00000029273 | sulfotransferase family 1D, member 1 |
Mus musculus | 69083 | sulfotransferase family, cytosolic, 1C, member 2 |
Oryza sativa | 4342402 | Os07g0148600 |
Oryza sativa | 9269362 | Os12g0137900 |
Oryza sativa | 9267617 | Os12g0137700 |
Oryza sativa | 9270598 | Os04g0359300 |
Oryza sativa | 4345031 | Os08g0239900 |
Oryza sativa | 4351454 | Os12g0137600 |
Oryza sativa | 9268444 | Os11g0450300 |
Oryza sativa | 4348233 | Os10g0190100 |
Oryza sativa | 4351955 | Os12g0270900 |
Oryza sativa | 4345205 | Os08g0297800 |
Oryza sativa | 9271579 | Os11g0505200 |
Oryza sativa | 4346028 | Os08g0515000 |
Oryza sativa | 4346029 | Os08g0515100 |
Oryza sativa | 4350564 | Os11g0503900 |
Oryza sativa | 4336454 | Os04g0526300 |
Oryza sativa | 4327280 | Os01g0311600 |
Oryza sativa | 9266577 | Os06g0252800 |
Oryza sativa | 4346532 | Os09g0256100 |
Oryza sativa | 9271189 | Os09g0555150 |
Oryza sativa | 4341575 | Os06g0626600 |
Oryza sativa | 4343853 | Os07g0605800 |
Oryza sativa | 4345032 | Os08g0240000 |
Onchocerca volvulus | OVOC6928 |
|
Onchocerca volvulus | OVOC12553 |
|
Schmidtea mediterranea | mk4.016599.01 | Sulfotransferase 6B1 |
Schmidtea mediterranea | mk4.001184.03 | Sulfotransferase 6B1 |
Schmidtea mediterranea | mk4.000122.02 | Sulfotransferase 6B1 |
Schmidtea mediterranea | mk4.017922.01 | Sulfotransferase 6B1 |
Toxoplasma gondii | TGME49_228140 | hypothetical protein |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.